Pairwise Sequence Alignment
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چکیده
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منابع مشابه
gpALIGNER: A Fast Algorithm for Global Pairwise Alignment of DNA Sequences
Bioinformatics, through the sequencing of the full genomes for many species, is increasingly relying on efficient global alignment tools exhibiting both high sensitivity and specificity. Many computational algorithms have been applied for solving the sequence alignment problem. Dynamic programming, statistical methods, approximation and heuristic algorithms are the most common methods appli...
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Background: Dialign is a DNA/Protein alignment tool for performing pairwise and multiple pairwise alignments through the comparison of gap-free segments (fragments) between sequence pairs. An alignment of two sequences is a chain of fragments, i.e local gap-free pairwise alignments, with the highest total score. METHOD: A new approach is defined in this article which relies on the concept of us...
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Given two sequences S1, S2, and a constrained sequence C, a longest common subsequence of S1, S2 with restriction to C is called a constrained longest common subsequence of S1 and S2 with C. At the same time, an optimal alignment of S1, S2 with restriction to C is called a constrained pairwise sequence alignment of S1 and S2 with C. Previous algorithms have shown that the constrained longest co...
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MOTIVATION Standard algorithms for pairwise protein sequence alignment make the simplifying assumption that amino acid substitutions at neighboring sites are uncorrelated. This assumption allows implementation of fast algorithms for pairwise sequence alignment, but it ignores information that could conceivably increase the power of remote homolog detection. We examine the validity of this assum...
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The goal of pairwise sequence alignment is to establish a correspondence between the elements in a pair of sequences that share a common property, such as common ancestry or a common structural or functional role. In computational biology, the sequences under consideration are typically nucleic acid or amino acid polymers. We will consider three variants of the pairwise sequence alignment probl...
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Sequence comparison is one of the most fundamental computational problems in bioinformatics. Pairwise sequence alignment methods align two sequences using a substitution matrix consisting of pairwise scores of aligning different residues with each other (like BLOSUM62), and give an alignment score for the given sequence-pair. This work 1 addresses the problem of accurately estimating statistica...
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